George L. Sutphin
Principal Investigator
Assistant Professor, Molecular & Cellular Biology
Assistant Professor, BIO5 Institute
Assistant Professor, Neuroscience GIDP
Assistant Professor, Cancer Biology GIDP
Assistant Professor, Genetics GIDP
Scientific Member, Arizona Center on Aging
Assistant Professor, BIO5 Institute
Assistant Professor, Neuroscience GIDP
Assistant Professor, Cancer Biology GIDP
Assistant Professor, Genetics GIDP
Scientific Member, Arizona Center on Aging
Office: BSRL 356
Lab: BSRL 317
Biography
George L. Sutphin, Ph.D., is an academic scientist at the University of Arizona focused on understanding the molecular basis of aging. He uses a combination of systems and comparative genetics to identify new molecular processes involved in aging and characterize their interaction with known environmental and genetic aging factors. By understanding the basic molecular architecture that underlies the aging process, the goal of Dr. Sutphin's work is to identify new targets for clinical intervention to extend healthy human lifespan and simultaneously treat or delay onset of multiple disease of aging, such as neurodegeneration, cancer, cardiovascular disease, and diabetes. Dr. Sutphin began his academic career as an engineer, earning a B.S. and M.S. in Aeronautics & Astronautics from the University of Washington in 2004 and 2006, respectively, before developing an interest in the basic biology of aging. He received his Ph.D. in Molecular & Cellular Biology from the University of Washington in 2012 and completed his post-doctoral training at The Jackson Laboratory in 2017. Dr. Sutphin was appointed Assistant Professor in Molecular & Cellular Biology at the University of Arizona in 2018
Dr. Sutphin is an active member of the broader aging research community. During his graduate and postdoctoral tenure he served on the trainee governance board at the Gerontological Society of America (GSA) and is currently a serving member of the Board of Directors of the American Aging Association (AGE). In addition to his primary appointment, he has affiliate appointments in the BIO5 Institute and the Arizona Center on Aging (ACOA) at the University of Arizona.
Research Interests
Education
Peer Reviewed Publications
* Joint first or senior author
Miller M, Fletcher M, Primitivo M, Leornard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF. Genetic interaction with temperature is an important determinant of nematode longevity. DOI: 10.1111/acel.12658. Aging Cell. (2017).
Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Meurs JBJ, Muribito JM, Johnson AD, Korstanje R. C. elegans Orthologs of Human Genes Differentially Expressed with Age are Enriched for Determinants of Longevity. Aging Cell DOI: 10.1111/acel.12595. (2017).
Mendenhall A, Crane MM, Leiser S, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R. Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. Journal of Gerontology: Biological Sciences DOI: 10.1093/gerona/glx017. (2017).
Sutphin GL*, Mahoney JM*, Shepard K, Walton DO, Korstanje R. WORMHOLE: Novel Least Diverged Ortholog Prediction Through Machine Learning. PLoS Computational Biology 12(11): e1005182. (2016).
Leiser SF, Jafari G, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, Kaeberlein M. Age-associated vulval integrity is an important marker of nematode healthspan. AGE 38:419 (2016).
McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Kaeberlein M, Kennedy BK, et al. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metabolism 22(5):895-906 (2015).
Chandler-Brown D, Choi H, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED, Kaeberlein M. Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Frontiers in Genetics 6:316 (2015).
Peters MJ*, Joehanes R*, Pilling LC*, Schurmann C*, Conneely KN*, Powell J*, Reinmaa E*, Sutphin GL*, Zhernakova A*, Schramm K*, Wilson YA*, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD, et al. The transcriptional landscape of age in human peripheral blood. Nature Communications 6:8570 (2015).
Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Mosely AM, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein K, Strathern JN, Duncan MC, Erie DA. Transcription Errors Induce Proteotoxic Stress and Shorten Cellular Lifespan. Nature Communications 6:8065 (2015).
Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Kennedy BK, Kaeberlein M, Berger SL, et al. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism 19(6):952-66 (2014) Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M, et al. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell 12(6):1050-1061 (2013).
Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sutphin GL, Vander Wende H, Kennedy BK, Kaeberlein M, et al. End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Research 13(3):267-276 (2013).
Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Kaeberlein M, et al. Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Experimental Gerontology 48(10):1006-1013 (2013).
Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wende HV, Kennedy BK, Kaeberlein M, et al. Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66 (2013).
Sutphin GL, Bishop E, Yanos ME, Moller RM, Kaeberlein M. Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longevity & Healthspan 1:9 (2012).
Murakami C, Delaney JR, Chow A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Kaeberlein M, et al. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle 11(16):3087-96 (2012).
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Houdinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez R, Orfila AM, Ackerman D, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Sőti C, Partridge L, Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011).
Delaney JR*, Sutphin GL*, Robison B, Schleit J, Murakami CJ, An EH, Carr D, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Suh Y, Zhou Z, Liu XG, Kennedy BK, Kaeberlein M. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10(6):1089-91 (2011).
Kruegel U, Robison B, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, Sutphin G, Carr D, Tar K, Dittmar G, Kaeberlein M, Kennedy BK, Schmidt M. Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genetics 7(9):e1002253 (2011).
Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans. Science 324(5931):1196-8 (May 2009).
Sutphin GL, Kaeberlein M. Measuring Caenorhabditis elegans Life Span on Solid Media. Journal of Visualized Experiments (May 2009).
Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7(3):394-404 (June 2008).
Sutphin GL, Kaeberlein M. Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Experimental Gerontology 43(3):130-5 (March 2008).
Reviews, Book Chapters, and Other Publications
Sutphin GL, Korstanje R. Longevity as a Complex Genetic Trait. In: Handbook of the Biology of Aging 8th Edition, Kaeberlein M, Martin GM, ed. Academic Press (2016).
Sutphin GL, Delaney JR, Kaeberlein MK. Replicative Life Span Analysis in Budding Yeast. Methods in Molecular Biology 1205:341-57 (2014).
Sutphin GL, Olsen BO, Kennedy BK, Kaeberlein M. Genome-wide analysis of yeast aging. Subcellular Biochemistry 57:251-89 (2012).
Sutphin GL, Kaeberlein M. Comparative Genetics of Aging. In: Handbook of the Biology of Aging 7th Edition, Masoro EJ, Austad SN, ed. Academic Press (2011).
Sutphin GL, Kennedy BK. Aging: Evolutionary Theory meets Genomic Approach. In: Evolutionary Biology: Concept, Modeling, and Application, Pontarotti P, ed. Springer Publishing (2009).
Ackay C, Sutphin GL, Jarboe TR, Sieck PE, Redd AJ, Nelson B, Isso VA. Ongoing NIMROD Simulations of The Lundquist Number and Lambda Dependence of the HIT-SI Plasma. American Physical Society, 48th Annual Meeting of the Division of Plasma Physics. October 30-November 3 (2006).
Sutphin GL. Computational Study of Lundquist Number and Injector Lambda in HIT-SI Using NIMROD. Master’s Thesis, University of Washington (June 2006).
Crocker AM, Sutphin GL, Cassisi DV, Knowlen C, Weimer RF. Investigation of enhanced vortex tube air separators for advanced space transportation. 40th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit. July 11-14 (2004).
George L. Sutphin, Ph.D., is an academic scientist at the University of Arizona focused on understanding the molecular basis of aging. He uses a combination of systems and comparative genetics to identify new molecular processes involved in aging and characterize their interaction with known environmental and genetic aging factors. By understanding the basic molecular architecture that underlies the aging process, the goal of Dr. Sutphin's work is to identify new targets for clinical intervention to extend healthy human lifespan and simultaneously treat or delay onset of multiple disease of aging, such as neurodegeneration, cancer, cardiovascular disease, and diabetes. Dr. Sutphin began his academic career as an engineer, earning a B.S. and M.S. in Aeronautics & Astronautics from the University of Washington in 2004 and 2006, respectively, before developing an interest in the basic biology of aging. He received his Ph.D. in Molecular & Cellular Biology from the University of Washington in 2012 and completed his post-doctoral training at The Jackson Laboratory in 2017. Dr. Sutphin was appointed Assistant Professor in Molecular & Cellular Biology at the University of Arizona in 2018
Dr. Sutphin is an active member of the broader aging research community. During his graduate and postdoctoral tenure he served on the trainee governance board at the Gerontological Society of America (GSA) and is currently a serving member of the Board of Directors of the American Aging Association (AGE). In addition to his primary appointment, he has affiliate appointments in the BIO5 Institute and the Arizona Center on Aging (ACOA) at the University of Arizona.
Research Interests
- Biology of Aging
- Comparative Genetics
- Systems Genetics
- Human Biology
- Mouse Biology
- Nematode Biology
Education
- Ph.D. in Molecular & Cellular Biology, University of Washington, 2012
- M.S. in Aeronautics & Astronautics, University of Washington, 2006
- B.S. in Aeronautics & Astronautics, University of Washington, 2006
Peer Reviewed Publications
* Joint first or senior author
Miller M, Fletcher M, Primitivo M, Leornard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF. Genetic interaction with temperature is an important determinant of nematode longevity. DOI: 10.1111/acel.12658. Aging Cell. (2017).
Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Meurs JBJ, Muribito JM, Johnson AD, Korstanje R. C. elegans Orthologs of Human Genes Differentially Expressed with Age are Enriched for Determinants of Longevity. Aging Cell DOI: 10.1111/acel.12595. (2017).
Mendenhall A, Crane MM, Leiser S, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R. Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. Journal of Gerontology: Biological Sciences DOI: 10.1093/gerona/glx017. (2017).
Sutphin GL*, Mahoney JM*, Shepard K, Walton DO, Korstanje R. WORMHOLE: Novel Least Diverged Ortholog Prediction Through Machine Learning. PLoS Computational Biology 12(11): e1005182. (2016).
Leiser SF, Jafari G, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, Kaeberlein M. Age-associated vulval integrity is an important marker of nematode healthspan. AGE 38:419 (2016).
McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Kaeberlein M, Kennedy BK, et al. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metabolism 22(5):895-906 (2015).
Chandler-Brown D, Choi H, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED, Kaeberlein M. Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Frontiers in Genetics 6:316 (2015).
Peters MJ*, Joehanes R*, Pilling LC*, Schurmann C*, Conneely KN*, Powell J*, Reinmaa E*, Sutphin GL*, Zhernakova A*, Schramm K*, Wilson YA*, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD, et al. The transcriptional landscape of age in human peripheral blood. Nature Communications 6:8570 (2015).
Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Mosely AM, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein K, Strathern JN, Duncan MC, Erie DA. Transcription Errors Induce Proteotoxic Stress and Shorten Cellular Lifespan. Nature Communications 6:8065 (2015).
Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Kennedy BK, Kaeberlein M, Berger SL, et al. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism 19(6):952-66 (2014) Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M, et al. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell 12(6):1050-1061 (2013).
Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sutphin GL, Vander Wende H, Kennedy BK, Kaeberlein M, et al. End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Research 13(3):267-276 (2013).
Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Kaeberlein M, et al. Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Experimental Gerontology 48(10):1006-1013 (2013).
Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wende HV, Kennedy BK, Kaeberlein M, et al. Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66 (2013).
Sutphin GL, Bishop E, Yanos ME, Moller RM, Kaeberlein M. Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longevity & Healthspan 1:9 (2012).
Murakami C, Delaney JR, Chow A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Kaeberlein M, et al. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle 11(16):3087-96 (2012).
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Houdinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez R, Orfila AM, Ackerman D, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Sőti C, Partridge L, Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011).
Delaney JR*, Sutphin GL*, Robison B, Schleit J, Murakami CJ, An EH, Carr D, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Suh Y, Zhou Z, Liu XG, Kennedy BK, Kaeberlein M. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10(6):1089-91 (2011).
Kruegel U, Robison B, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, Sutphin G, Carr D, Tar K, Dittmar G, Kaeberlein M, Kennedy BK, Schmidt M. Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genetics 7(9):e1002253 (2011).
Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans. Science 324(5931):1196-8 (May 2009).
Sutphin GL, Kaeberlein M. Measuring Caenorhabditis elegans Life Span on Solid Media. Journal of Visualized Experiments (May 2009).
Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7(3):394-404 (June 2008).
Sutphin GL, Kaeberlein M. Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Experimental Gerontology 43(3):130-5 (March 2008).
Reviews, Book Chapters, and Other Publications
Sutphin GL, Korstanje R. Longevity as a Complex Genetic Trait. In: Handbook of the Biology of Aging 8th Edition, Kaeberlein M, Martin GM, ed. Academic Press (2016).
Sutphin GL, Delaney JR, Kaeberlein MK. Replicative Life Span Analysis in Budding Yeast. Methods in Molecular Biology 1205:341-57 (2014).
Sutphin GL, Olsen BO, Kennedy BK, Kaeberlein M. Genome-wide analysis of yeast aging. Subcellular Biochemistry 57:251-89 (2012).
Sutphin GL, Kaeberlein M. Comparative Genetics of Aging. In: Handbook of the Biology of Aging 7th Edition, Masoro EJ, Austad SN, ed. Academic Press (2011).
Sutphin GL, Kennedy BK. Aging: Evolutionary Theory meets Genomic Approach. In: Evolutionary Biology: Concept, Modeling, and Application, Pontarotti P, ed. Springer Publishing (2009).
Ackay C, Sutphin GL, Jarboe TR, Sieck PE, Redd AJ, Nelson B, Isso VA. Ongoing NIMROD Simulations of The Lundquist Number and Lambda Dependence of the HIT-SI Plasma. American Physical Society, 48th Annual Meeting of the Division of Plasma Physics. October 30-November 3 (2006).
Sutphin GL. Computational Study of Lundquist Number and Injector Lambda in HIT-SI Using NIMROD. Master’s Thesis, University of Washington (June 2006).
Crocker AM, Sutphin GL, Cassisi DV, Knowlen C, Weimer RF. Investigation of enhanced vortex tube air separators for advanced space transportation. 40th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit. July 11-14 (2004).