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Our goal is to understand the molecular basis of aging, and leverage this understanding to develop new clinical interventions to extend healthy human lifespan and treat age-associated disease.
We use a combination of systems and comparative genetics to identify new molecules capable of influencing lifespan, characterize their mechanistic role in aging, and understand their interaction with other aging processes. By building a working model of the molecular networks that drive age-associated functional deterioration we can identify key targets for clinical intervention.