Publications

Refereed Journal Articles:

*,** authors contributed equally

  1. Sutphin GL, Kaeberlein M. Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Experimental Gerontology 43(3):130-5 (March 2008). [PubMed]

  2. Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7(3):394-404 (June 2008). [PubMed]

  3. Sutphin GL, Kaeberlein M. Measuring Caenorhabditis elegans Life Span on Solid Media. Journal of Visualized Experiments 27:1152 (May 2009). [PubMed]

  4. Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans. Science 324(5931):1196-8 (May 2009). [PubMed]

  5. Kruegel U, Robison B, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, Sutphin G, Carr D, Tar K, Dittmar G, Kaeberlein M, Kennedy BK*, Schmidt M*. Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genetics 7(9):e1002253 (2011). [PubMed]

  6. Delaney JR*, Sutphin GL*, Robison B, Schleit J, Murakami CJ, An EH, Carr D, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Suh Y, Zhou Z, Liu XG*, Kennedy BK*, Kaeberlein M*. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10(6):1089-91 (2011). [PubMed]

  7. Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Houdinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez R, Orfila AM, Ackerman D, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Sőti C, Partridge L, Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011). [PubMed]

  8. Murakami C*, Delaney JR*, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong K, Kim JR, Klum S, Liao E, Lin MS, Low W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle 11(16):3087-96 (2012). [PubMed]

  9. Sutphin GL, Bishop E, Yanos ME, Moller RM, Kaeberlein M. Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longevity & Healthspan 1:9 (2012). [PubMed]

  10. Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, An EH, Castanza A, Fletcher M, Higgins S, Jelic M, Klum S, Muller B, Peng ZJ, Rai D, Ros V, Singh M, Vander Wende H, Kennedy BK, Kaeberlein M. Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66 (2013). [PubMed]

  11. Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong K, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M. Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Experimental Gerontology 48(10):1006-1013 (2013). [PubMed]

  12. Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sim S, An EH, Castanza AS, Fletcher M, Higgins S, Holmberg M, Hui J, Jelic M, Jeong K, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schleit J, Schuster A, Singh M, Spector BL, Sutphin GL, Wang AM, Wasko BM, Vander Wende H, Kennedy BK, Kaeberlein M. End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Research 13(3):267-276 (2013). [PubMed]

  13. Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Holmberg M, Jeong K, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Vander Wende H, An EH, Fletcher M, Jelic M, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M*. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell 12(6):1050‑1061 (2013). [PubMed]

  14. Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism 19(6):952-66 (2014). [PubMed]

  15. Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Mosely AM, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. Transcription Errors Induce Proteotoxic Stress and Shorten Cellular Lifespan. Nature Communications 6:8065 (2015). [PubMed]

  16. Peters MJ*, Joehanes R*, Pilling LC*, Schurmann C*, Conneely KN*, Powell J*, Reinmaa E*, Sutphin GL*, Zhernakova A*, Schramm K*, Wilson YA*, Kobes S, Tukiainen T, NABEC/UKBEC Consortium, Ramos YF, Göring HHH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MMPJ, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe H, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra H, McRae AF, Smith JA, Kardia SLR, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy‑Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YI, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean Sb, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J**, Franke L**, Kettunen J**, Visscher PM**, Neely GG**, Korstanje R**, Hanson RL**, Prokisch H**, Ferrucci L**, Esko T**, Teumer A**, van Meurs JB**, Johnson AD**. The transcriptional landscape of age in human peripheral blood. Nature Communications 6:8570 (2015). [PubMed]

  17. Chandler-Brown D* , Choi H*, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED**, Kaeberlein M**. Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Frontiers in Genetics 6:316 (2015). [PubMed]

  18. McCormick MA*, Delaney JR*, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong K, Johnston E, Kerr EO, Kim Ju, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RMu, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao PN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu X, Suh Y, Zhou Z, Kaeberlein M**, Kennedy BK**. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metabolism 22(5):895-906 (2015). [PubMed]

  19. Sutphin GL*, Mahoney JM*, Shepard K, Walton DO, Korstanje R. WORMHOLE: Novel Least Diverged Ortholog Prediction Through Machine Learning. PLoS Computational Biology 12(11): e1005182 (2016). [PubMed]

  20. Leiser SF* Jafari G*, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, Kaeberlein M. Age-associated vulval integrity is an important marker of nematode healthspan. AGE 38(5-6):419-431 (2016). [PubMed]

  21. Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Meurs JBJ, Muribito JM, Johnson AD, Korstanje R. C. elegans Orthologs of Human Genes Differentially Expressed with Age are Enriched for Determinants of Longevity. Aging Cell 16(4):672-682 (2017). [PubMed]

  22. Mendenhall A, Crane MM, Leiser S, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R. Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. Journal of Gerontology: Biological Sciences. 72(8):1033-1037 (2017). [PubMed]

  23. Miller M, Fletcher M, Primitivo M, Leornard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF. Genetic interaction with temperature is an important determinant of nematode longevity. Aging Cell 16(6):1425-1429. (2017). [PubMed]

  24. Bubier JA*, Sutphin GL*, Reynolds TJ, Korstanje R, Fuksman-Kumpa A, Baker EJ, Langston MA, Chesler, EJ. Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species. PLoS One 14(4):e0214523. (2019). [PubMed]

  25. Castro-Portuguez R, Sutphin GL. Kynurenine pathway, NAD+ synthesis, and mitochondrial function: targeting tryptophan metabolism to promote longevity and healthspan. Experimental Gerontology 2020;110841. doi:10.1016/j.exger.2020.110841 (Jan 2020). [PubMed]

  26. Gardea EA, DeNicola D, Freitas S, Peterson W, Dang H, Shuck K, Fang-Yen C, Sutphin GL. Long‑Term Culture and Monitoring of Isolated Caenorhabditis elegans on Solid Media in Multi-Well Devices. Journal of Visualized Experiments 190, e64681. doi:10.3791/64681 (Dec 2022). [PubMed]

  27. Espejo L*, Hull B*, Chang LM, DeNicola D, Freitas S, Silbar V, Haskins A, Turner EA, Sutphin GL. Long-Term Culture and Monitoring of Isolated Caenorhabditis elegans on Solid Media in Multi-Well Devices. Journal of Visualized Experiments 190, e64682. doi:10.3791/64682 (Dec 2022). [PubMed]

  28. Dang H*, Castro-Portuguez R*, Espejo L*, Backer G, Freitas S, Spence E, Meyers J, Gardea EA, Shuck K, Corban C, Liu T, Bean S, Sheehan S, Korstanje R**, Sutphin GL**. On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging. Nature Communications 14, 8338. doi: 10.1038/s41467-023-43527-1 (2023). [PubMed]

  29. Soucy A, Potts C, Kaija A, Harrington A, McGilvrey M, Sutphin GL, Korstanje R, Tero B, Seeker J, Pinz I, Vary C, Ryzhova L, Liaw L. Effects of a Global Rab27a Null Mutation on Murine PVAT and Cardiovascular Function. Arterioscler Thromb Vasc Biol. 2024 Apr 25;. doi: 10.1161/ATVBAHA.124.320969. [Epub ahead of print] PubMed PMID: 38660803. [PubMed]

  30. Hull BT, Miller KM, Corban C, Backer G, Sheehan S, Korstanje R, Sutphin GL. 3-hydroxyanthranilic acid delays paralysis in Caenorhabditis elegans models of amyloid-beta and polyglutamine proteotoxicity. Biomolecules 14(5), 599. doi: 10.3390/biom14050599 (2024). [PubMed]

  31. Huang S, Cox RL, Tuckowski A, Beydoun S, Bhat A, Howington MB, Sarker M, Miller H, Ruwe E, Wang E, Li X, Gardea EA, DeNicola D, Peterson W, Carrier JM, Miller RA, Sutphin GL, Leiser SF. Fmo induction as a tool to screen for pro-longevity drugs. GeroScience. doi:  10.1007/s11357-024-01207-y (2024). [PubMed]

 Works in Progress

  1. Castro-Portuguez, Miller KM, Thullen E, Hendrickson AM, Freitas S, Hull B, Meyers JB, Thorns N, Gardea EA, Dang H, Espejo LS, Sutphin GL. Inhibition of haao-1 enhances oxidative stress response by activating hormetic redox signaling in C. elegans. bioRxiv 2023.02.16.528568. doi:10.1101/2023.02.16.528568. [bioRxiv]

  2. Espejo L, DeNicola D, Chang LM, Hofschneider V, Haskins A, Balsa J, Freitas SS, Antenor A, Hamming S, Hull B, Castro-Portuguez R, Dang H, Sutphin GL. The Emerging Role of 3‑Hydroxyanthranilic Acid on C. elegans Aging Immune Function. bioRxiv 2024.01.07.574394. doi:10.1101/2024.01.07.574394. [bioRxiv]

  3. Espejo L, Freitas S, Hofschneider V, Chang L, Balsa J, Antenor A, Dang H, DeNicola D, Sutphin GL. SICKO: Systematic Imaging of Caenorhabditis Killing Organisms. bioRxiv 2023.02.17.529009. doi:10.1101/2023.02.17.529009. [bioRxiv]

  4. Hull BT, Irby IM, Miller KM, Anderson A, Gardea EA, Sutphin GL. Experimental variables that impact outcomes in Caenorhabditis elegans aging stress response. bioRxiv 2024.01.09.574889. doi:10.1101/2024.01.09.574889. Preparing for submission to Geroscience.

  5. Railey R, Robinson L, Garland G, Korstanje R, Sutphin GL. Male-specific lifespan extension from dietary 3-hydroxyanthanilic acid initiated late in life in mice. Preparing submission for Geroscience. 

  6. Freitas S, DeNicola D, Hofschneider V, Gardea EA, Peterson W, Kelser D, Hendrickson A, Sutphin GL. Worm Paparazzi—An automated platform for longevity and healthspan quantification in individual Caenorhabditis elegans. In preparation for submission to Geroscience.

  7. Castro-Portuguez R, Miller KM, Thorns N, Sutphin GL. 3-hydroxyanthranilic acid prevents ferroptosis but fails to prevent hydrogen peroxide- and paraquat-induced cell death. Preparing for submission to Cancer Research.

  8. Miller KM, Rounseville S, Castro-Portuguez R, Dang H, Railey R, Dundore K, Espejo E, Hofschneider V, Sutphin GL. Kynurenine Metabolism Mediates Tumor Progression in Murine Renal Cell Carcinoma. In preparation.

  9. Sutphin GL, Backer G, Bean S, Sheehan S, Savage H, Gott R, Takemon Y, Korstanje R. Developmental and longevity consequences of GRASP55 knockout in C. elegans and mice. In preparation.

  10. Sutphin GL, Backer G, Bean S, Sheehan S, Savage H, Gott R, Takemon Y, Korstanje R. RAB27A knockout extends lifespan in C. elegans but not mice. In preparation.

  11. Kehoe S, Kondrikov D, Wang G, McGee-Lawrence ME, Fulzele S, Sutphin GL, Hill WD. The interplay between the kynurenine pathway, cellular senescence, and age-related disease in skeletal and brain tissue. In preparation.

  12. Freitas S, Castro-Portuguez R, Ulrich M, Gardea EA, Sutphin GL. LightSaver—A tool for rapid fluorescence quantification in individual C. elegans. In preparation.

  13. Gardea EA, Peterson W, Furtmann A, Dang H, DeNicola D, Espejo L, Castro-Portuguez R, Freitas S, Sutphin GL. Cadmium sensitizes C. elegans to osmotic stress by disrupting glycerol production. In preparation.

  14. Chang L*, Haskins A*, Espejo L, Sutphin GL. Mechanisms of inter-tissue trafficking and localization of 3‑hydroxyanthranilic acid in Caenorhabditis elegans. In preparation.

  15. Hull BT, Irby IM, Anderson A, Gardea EA, Haskins A, Peterson W, Furtmann A, Shuck K, Meyers J, Espejo L, Freitas S, Dang H, Sutphin GL. Metals form a node in the C. elegans cellular stress network. In preparation.

  16. Hull BT, Irby IM, Anderson A, Gardea EA, Sutphin GL. Mechanism of copper toxicity and protection against proteotoxicity in C. elegans. In preparation.

Chapters in Scholarly Books & Monographs:

  1. Sutphin GL, Kennedy BK. Aging: Evolutionary Theory meets Genomic Approach. In: Evolutionary Biology: Concept, Modeling, and Application, Pontarotti P, ed. Springer Publishing (2009). [webpage]

  2. Sutphin GL, Kaeberlein M. Comparative Genetics of Aging. In: Handbook of the Biology of Aging 7th Edition, Masoro EJ, Austad SN, ed. Academic Press (2011). [webpage]

  3. Sutphin GL, Olsen BO, Kennedy BK, Kaeberlein M. Genome-wide analysis of yeast aging. Subcellular Biochemistry 57:251-89 (2012). [PubMed]

  4. Sutphin GL, Delaney JR, Kaeberlein MK. Replicative Life Span Analysis in Budding Yeast. Methods in Molecular Biology 1205:341-57 (2014). [PubMed]

  5. Sutphin GL, Korstanje R. Longevity as a Complex Genetic Trait. In: Handbook of the Biology of Aging 8th Edition, Kaeberlein M, Martin GM, ed. Academic Press (2016). [webpage]

  6. Sutphin GL, Korstanje R. Longevity as a Complex Genetic Trait. In: Handbook of the Biology of Aging 9th Edition, Musi N, Hornsby PJ, ed. Academic Press (2021). [PubMed]

Other Publications:

  1. Crocker AM, Sutphin GL, Cassisi DV, Knowlen C*, Weimer RF*. Investigation of enhanced vortex tube air separators for advanced space transportation. 40th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit. July 11-14 (2004).

  2. Sutphin GL. Computational Study of Lundquist Number and Injector Lambda in HIT-SI Using NIMROD. Master’s Thesis, University of Washington (June 2006).

  3. Ackay C, Sutphin GL, Jarboe TR, Sieck PE, Redd AJ, Nelson B, Isso VA. Ongoing NIMROD Simulations of The Lundquist Number and Lambda Dependence of the HIT-SI Plasma. American Physical Society, 48th Annual Meeting of the Division of Plasma Physics. October 30-November 3 (2006).

  4. Sutphin GL. A new defense in the battle of the sexes. eLife 8:e50140. (August 2019). [PubMed]

  5. Freitas S. [University of Arizona Thesis Repository]

Patents:

  1. U.S. Provisional Application No. 62/798,708
    COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES OR CONDITIONS
    Filing Date: 28 July 2021

  2. International Patent Application No. PCT/US2020/015855
    COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES OR CONDITIONS
    Filing Date: 30 January 2020

  3. U.S. Patent Application No. 17/426,416
    COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES OR CONDITIONS
    Filing Date: 28 July 2021

  4. U.S. Provisional Application No. 63/263,769
    COMPOSITIONS CONTAINING 3-HYDROXYANTHRANILIC ACID AND COMPOUNDS THAT ALTER IRON HOMEOSTASIS AND METHOD OF ITS USE
    Filing Date: 9 November 2021

  5. U.S. Provisional Application No. 63/357,425
    SYSTEMS AND METHODS FOR A NOVEL IMAGE-BASED MULTI-OMICS CLOCK FOR THE PREDCITION OF REMAINING LIFESPAN
    Filing Date: 30 June 2022

  6. International Patent Application No. PCT/US2022/049368
    COMPOSITIONS CONTAINING 3-HYDROXYANTHRANILIC ACID AND COMPOUNDS THAT ALTER IRON HOMEOSTASIS AND METHOD OF ITS USE
    Filing Date: 9 November 2022

  7. U.S. Provisional Application No. 63/429,015
    A HIGH-THROUGHPUT PLATFORM FOR MEASURING LIFESPAN AND MULTIPLE IN VIVO MOLECULAR BIOMARKERS OF AGING
    Filing Date: 30 November 2022

  8. U.S. Patent Application No. 63/448,539
    HIGH-THROUGHPUT PLATFORM FOR MEASURING LIFESPAN AND MULTIPLE IN VIVO MOLECULAR BIOMARKERS OF AGING
    Filing Date: 27 February 2023

  9. U.S. Provisional Application No. 63/448,557
    DATA ANALYSIS FOR HIGH-THROUGHPUT EXPERIMENTS FOR MEASURING LIFESPAN AND MULTIPLE IN VIVO MOLECULAR BIOMARKERS OF AGING
    Filing Date: 27 February 2023

  10. U.S. Provisional Application No. 63/494,33
    SYSTEMS AND METHODS FOR IMAGING ANIMALS
    Filing Date: 5 April 2024

  11. International Patent Application No. PCT/US2023/069388
    SYSTEMS AND METHODS FOR A NOVEL IMAGE-BASED MULTI-OMICS CLOCK FOR THE PREDCITION OF REMAINING LIFESPAN
    Filing Date: 29 June 2023

  12. International Patent Application No. PCT/US2023/081314
    PLATFORM, SYSTEM, AND ASSOCIATED PROCESSES FOR MEASURING LIFESPAN AND MULTIPLE IN VIVO MOLECULAR BIOMARKERS OF AGING
    Filing Date: 28 November 2023

Software and Websites:

  1. Sutphin, GL. MCB 585 – Multidisciplinary/Quantitative Approaches to Solving Biological Problems. Course Website (2019). [webpage]

  2. Freitas, S. SICKO - Systematic Imaging of Caenorhabditis Killing Organisms. https://github.com/Sam-Freitas/SICKO (2023). [GitHub]

  3. Espejo, L. SICKO Analysis. https://github.com/lespejo1990/SICKO_Analysis (2023). [GitHub]

  4. Freitas, S. LightSaver – Fluorescent analysis of individualized C. elegans. https://github.com/Sam-Freitas/LightSaver (2023). [GitHub]

  5. Freitas, S. Entropy DIC – 2D entropy filter-based segmentation of cultured cell images. https://github.com/Sam-Freitas/entropy_DIC (2023). [GitHub]