Publications

2017201620152014201320122011201020092008

* Joint first author ** Joint senior author

2017

Miller M, Fletcher M, Primitivo M, Leornard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF. Genetic interaction with temperature is an important determinant of nematode longevity. DOI: 10.1111/acel.12658. Aging Cell. (2017). PMID: 28940623.

Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Meurs JBJ, Muribito JM, Johnson AD, Korstanje R. C. elegans Orthologs of Human Genes Differentially Expressed with Age are Enriched for Determinants of Longevity. Aging Cell DOI: 10.1111/acel.12595. (2017). PMID: 28401650.

Mendenhall A, Crane MM, Leiser S, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R. Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. Journal of Gerontology: Biological Sciences DOI: 10.1093/gerona/glx017. (2017). PMID: 28369388.

2016

Sutphin GL*, Mahoney JM*, Shepard K, Walton DO, Korstanje R. WORMHOLE: Novel Least Diverged Ortholog Prediction Through Machine Learning. PLoS Computational Biology 12(11): e1005182. (2016). PMID: 27812085.

Leiser SF, Jafari G, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, Kaeberlein M. Age-associated vulval integrity is an important marker of nematode healthspan. AGE 38:419 (2016). PMID: 27566309.

Sutphin GL, Korstanje R. Longevity as a Complex Genetic Trait. In: Handbook of the Biology of Aging 8th Edition, Kaeberlein M, Martin GM, ed. Academic Press (2016).

2015

Chandler-Brown D*, Choi H*, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED, Kaeberlein M. Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Frontiers in Genetics 6:316 (2015). PMID: 26579191.

Peters MJ*, Joehanes R*, Pilling LC*, Schurmann C*, Conneely KN*, Powell J*, Reinmaa E*, Sutphin GL*, Zhernakova A*, Schramm K*, Wilson YA*, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J**, Franke L**, Kettunen J**, Visscher PM**, Neely GG**, Korstanje R**, Hanson RL**, Prokisch H**, Ferrucci L**, Esko T**, Teumer A**, van Meurs JB**, Johnson AD**. The transcriptional landscape of age in human peripheral blood. Nature Communications 6:8570 (2015). PMID: 26490707.

Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Mosely AM, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein K, Strathern JN, Duncan MC, Erie DA. Transcription Errors Induce Proteotoxic Stress and Shorten Cellular Lifespan. Nature Communications 6:8065 (2015). PMID: 26304740.

2014

Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism 19(6):952-66 (2014). PMID: 24814484.

Sutphin GL, Delaney JR, Kaeberlein MK. Replicative Life Span Analysis in Budding Yeast. Methods in Molecular Biology 1205:341-57 (2014). PMID: 25213254.

2013

Schleit J*, Johnson SC*, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Holmberg M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Vander Wende H, An EH, Fletcher M, Jelic M, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell 12(6):1050-1061 (2013). PMID: 23837470.

Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sim S, An EH, Castanza AS, Fletcher M, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schleit J, Schuster A, Singh M, Spector BL, Sutphin GL, Wang AM, Wasko BM, Vander Wende H, Kennedy BK, Kaeberlein M. End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Research 13(3):267-276 (2013). PMID: 23336757.

Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Wende HV, Wang AM, Wasko BM, Olsen B, Kaeberlein M. Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Experimental Gerontology 48(10):1006-1013 (2013). PMID: 23235143.

Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, An EH, Castanza A, Fletcher M, Higgins S, Jelic M, Klum S, Muller B, Peng ZJ, Rai D, Ros V, Singh M, Wende HV, Kennedy BK, Kaeberlein M. Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66 (2013). PMID: 23167605.

2012

Sutphin GL, Bishop E, Yanos ME, Moller RM, Kaeberlein M. Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longevity & Healthspan 1:9 (2012). PMID: 24764514.

Murakami C*, Delaney JR*, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle 11(16):3087-96 (2012). PMID: 22871733.

Sutphin GL, Olsen BO, Kennedy BK, Kaeberlein M. Genome-wide analysis of yeast aging. Subcellular Biochemistry 57:251-89 (2012). PMID: 22094426.

2011

Burnett C*, Valentini S*, Cabreiro F*, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011). PMID: 21938067.

Delaney JR*, Sutphin GL*, Robison B, Schleit J, Murakami CJ, An EH, Carr D, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Suh Y, Zhou Z, Liu XG, Kennedy BK, Kaeberlein M. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10(6):1089-91 (2011). PMID: 21902802.

Kruegel U*, Robison B*, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, Sutphin G, Carr D, Tar K, Dittmar G, Kaeberlein M, Kennedy BK, Schmidt M. Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genetics 7(9):e1002253 (2011). PMID: 21931558.

Sutphin GL, Kaeberlein M. Comparative Genetics of Aging. In: Handbook of the Biology of Aging 7th Edition, Masoro EJ, Austad SN, ed. Academic Press (2011).

2010

2009

Mehta R*, Steinkraus KA*, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans. Science 324(5931):1196-8 (May 2009). PMID: 19372390.

Sutphin GL, Kaeberlein M. Measuring Caenorhabditis elegans Life Span on Solid Media. Journal of Visualized Experiments (May 2009). PMID: 19488025.

Sutphin GL, Kennedy BK. Aging: Evolutionary Theory meets Genomic Approach. In: Evolutionary Biology: Concept, Modeling, and Application, Pontarotti P, ed. Springer Publishing (2009).

2008

Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7(3):394-404 (June 2008). PMID: 18331616.

Sutphin GL, Kaeberlein M. Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Experimental Gerontology 43(3):130-5 (March 2008). PMID: 18083317.